Purchase 98% Pure JWH-018 Powder Online. JWH-018 is a synthetic cannabinoid that is structurally similar to THC, the psychoactive ingredient in cannabis. It was first developed in the 1990s by John W. Huffman, a professor of organic chemistry at Clemson University. JWH-018 is a popular research chemical and has been found to produce …Only include results for this siteHide site from these resultsShare feedback about this site.
1-Pentyl-3-(1-naphthoyl)indole (also called AM-678 and JWH-018)[1][2] is a full agonist synthetic cannabinoid first synthesized by organic chemist John W. Huffman. It gained popularity in late 2008 when German chemists found it as a chemical within the popular synthetic cannabis blend Spice, which had been sold in numerous countries around the world since 2002.[3][4][5]
Cannabinoids are commonly smoked or vaporized to achieve a quick onset of effects and rapid offset. JWH-018 is orally active when dissolved in a lipid, which can increase the duration significantly. Like other cannabinoids, it is insoluble in water but dissolves in ethanol and lipids.
Unlike cannabis, the chronic abuse of synthetic cannabinoids has been associated with multiple deaths and more dangerous side effects and toxicity in general. Therefore, it is very strongly discouraged to take this substance for extended periods of time or in excessive doses
Chemistry
JWH-018, or Naphthalen-1-yl-(1-pentylindol-3-yl)methanone, is a synthetic cannabinoid containing a substituted indole structure. This indole core is shared with other cannabinoid substances including PB-22, 5F-PB-22, JWH-018, and AM2201. JWH-018 is substituted at R1 with a pentyl chain. Additionally, the indole core is substituted at R3 with a carbonyl group which is also bonded to a napthalene moeity. Napthalene is a bicyclic structure of two fused benzene rings. This carbonyl bridge of JWH-018 classifies it as a ketone. JWH-018 is an analog of THJ-018, in which the core indazole structure is substituted with an indole base.
Pharmacology
JWH-018 is a full agonist of both the CB1 and CB2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB1 and 2.94 ± 2.65 nM at CB2.[6] However, the role of these interactions and how it results in the cannabinoid high experience continues to remain elusive.
Physical effects
- Spontaneous physical sensations – The “body high” of JWH-018 can be described as a warm, soft, and often full body tingling sensation that spreads over the body. It maintains a consistent presence that quickly rises with the onset and hits its limit once the peak has been reached before immediately dissipating. It is often described as being synthetic in feel and not as pleasant or as encompassing as the body high given by traditional cannabis. The JWH-018 body high has also been described by some as being slightly anxiety-inducing or even flat out uncomfortable when compared to the effects given by natural cannabinoids.
- Sedation – Generally, the effects on the user’s energy levels are sedating. This encourages one to relax, lie down, and (at higher doses) fall asleep. It produces strong sedative effects that can be described as on par with 5F-PB-22 and more sedating when compared to THC, JWH-073, THJ-018, AM-2201, or 5F-UR-144 but less than that of 5F-AKB48. Purchase JWH-018
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Cognitive effects
- Emotion enhancement – The most prominent cognitive component of cannabinoids is the way in which they enhance the emotions one is already feeling proportional to dose. This can result in euphoria, extreme laughter, and increased immersion within tasks and activities, or it can result in anxiety and paranoia depending on the user’s current state of mind.
- Euphoria – This can be considered very prominent in comparison to THJ-018, AM-2201, and 5F-UR-144 but less intense in comparison to JWH-073.
- Thought connectivity – This can attribute to fluid, more abstract thinking in comparison to linear thought.
- Anxiety – Subjectively, JWH-018 is less anxiogenic and stimulating than Δ9-THC, THJ-018, AM-2201, or 5F-UR-144 but more so than JWH-073. This effect is countered by use of benzodiazepines, other anti-anxiety agents, and a comfortable setting and also lessens with tolerance.
- Panic attacks – JWH-018 is readily capable of inducing a panic attack at higher doses. Typically, it surfaces from paranoia, involves feelings of soon death, feelings of impending doom,